Optic Nerve Hydropic Axonal Degeneration and Blocked Retrograde Axoplasmic Transport
نویسندگان
چکیده
منابع مشابه
Inhibition of retrograde axoplasmic transport in rat optic nerve by increased IOP in vitro.
Horseradish peroxidase (HRP) injected into one lateral geniculate nucleus of hooded rats, is taken up by terminals of the optic nerve and transported retrogradely towards the opposite retina. Four hours after injection, a small portion of HRP has reached the retina. After excision of the bulb and optic nerve and another 4 hours of in vitro transport during which different levels of intraocular ...
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PURPOSE Disturbed axonal transport is an important pathogenic factor in many neurodegenerative diseases, such as glaucoma, an eye disease characterised by progressive atrophy of the optic nerve. Quantification of retrograde axonal transport in the optic nerve usually requires labour intensive histochemical techniques or expensive equipment for in vivo imaging. Here, we report on a robust altern...
متن کاملPolyol metabolism of retrograde axonal transport in diabetic rat large optic nerve fiber.
PURPOSE The role of the polyol pathway metabolism in progressive impairment of retrograde axonal transport was evaluated in the optic nerve of rats with streptozotocin-induced diabetes. METHODS Rats with streptozotocin-induced diabetes received a low (3 mg/kg body weight) or high dose (10 mg/kg body weight) of oral aldose reductase inhibitor (ARI). At 1 and 3 months after induction of diabete...
متن کاملOcular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration.
Ocular hypertension (OHT) is the main risk factor of glaucoma, a neuropathy leading to blindness. Here we have investigated the effects of laser photocoagulation (LP)-induced OHT, on the survival and retrograde axonal transport (RAT) of adult rat retinal ganglion cells (RGC) from 1 to 12 wks. Active RAT was examined with fluorogold (FG) applied to both superior colliculi (SCi) 1 wk before proce...
متن کاملRetrograde axonal transport of endogenous phospholipids in rat sciatic nerve.
Anterograde axonal transport of phospholipids occurs at a rate of several hundred millimeters per day. However, although labeled precursors are incorporated into phospholipids in the neuronal cell bodies within several hours, these newly synthesized phospholipids are committed to transport over a much longer period of time. Thus, maximal accumulation of radioactive lipids in axons and nerve end...
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ژورنال
عنوان ژورنال: Archives of Ophthalmology
سال: 2007
ISSN: 0003-9950
DOI: 10.1001/archopht.125.3.347